A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases
oleh: Jasmina S. Redzic, Jeremy Rahkola, Norman Tran, Todd Holyoak, Eunjeong Lee, Antonio Javier MartÃn-Galiano, Nancy Meyer, Hongjin Zheng, Elan Eisenmesser
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Cryo-EM reveals the structure of the IgA1 metalloprotease (IgA1P) from the pathogen, G. haemolysans in the absence and presence of IgA substrate, which suggests a conserved gating mechanism for IgA1P enzymes and provides a basis for therapeutic strategies.