Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case
oleh: Laura Chiecchio, Gian Paolo Dagrada, Rebecca K.M. Protheroe, David M. Stockley, Alastair G. Smith, Kim H. Orchard, Nicholas C.P. Cross, Christine J. Harrison, Fiona M. Ross
| Format: | Article |
|---|---|
| Diterbitkan: | Ferrata Storti Foundation 2009-07-01 |
Deskripsi
We report serial genetic studies on a young female patient initially diagnosed with asymptomatic smouldering myeloma who progressed to symptomatic myeloma 4.5 years after presentation. An unbalanced translocation, der(14)t(4;14)(p16;q32), was initially found in all plasma cells plus deletions of other chromosomal regions as detected by array-based comparative genomic hybridization. Deletion of chromosome 13 was observed in a minor population of plasma cells (