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Plasma cell osteomyelitis, characterised by abundance of plasma cells in the lesional bone is a rare entity. We report a case of chronic plasma cell osteomyelitis in a 14-year-old male child who presented with complaints of pain in right leg and fever. The X-ray AP view of right leg revealed a cavitary lytic lesion with a sclerotic border in proximal one third of right tibia. A clinical diagnosis of Brodie’s abscess was favoured. Histopathological examination revealed sheets of plasma cells, many neutrophils and lymphocytes, areas of fibrosis and spicules of dead bone. Immunohistochemistry revealed polyclonal population of plasma cells which were both Kappa and Lambda light chain positive. We recommend diligent histopathological examination and correlation with clinico-radiological profile for a correct diagnosis and in order to avoid an over diagnosis of neoplastic plasma cell lesion.