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Background: The aim of this study was to identify the effects of smoking on bone healing and other complications encountered in the treatment and follow-up of distal femur fracture. Materials and Methods: A total of 54 patients with AO Type B and C distal femur fracture were included during the study. All the patients were treated with distal locking compression plating. Functional outcome was recorded on the basis of the American knee society scoring system. Results: The mean radiological union time and incidence of postoperative infection were significantly higher in smokers as compared to nonsmokers. Total American knee society score was similar in both the groups. Conclusion: Smoking cessation should be advised following fracture fixation.