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<i>Panax ginseng</i> Meyer cv. Silvatica (PGS), which is also known as &#8220;Lin-Xia-Shan-Shen&#8222; or &#8220;Zi-Hai&#8222; in China, is grown in forests and mountains by broadcasting the seeds of ginseng and is harvested at the cultivation age of 15&#8211;20 years. In this study, four new dammarane-type triterpenoids, ginsengenin-S1 (<b>1</b>), ginsengenin-S2 (<b>2</b>), ginsenoside-S3 (<b>3</b>), ginsenoside-S4 (<b>4</b>), along with one known compound were isolated from pearl knots of PGS. Ginsengenin-S2 significantly alleviated oxidative damage when A549 cells were exposed to cigarette smoke (CS) extract. In addition, ginsengenin-S2 could inhibit the CS-induced inflammatory reaction in A549 cells. Protective effects of ginsengenin-S2 against CS-mediated oxidative stress and the inflammatory response in A549 cells may involve the Nrf2 and HDAC2 pathways.