TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine
oleh: David Alarcón-Alarcón, David Cabañero, Jorge de Andrés-López, Magdalena Nikolaeva-Koleva, Simona Giorgi, Gregorio Fernández-Ballester, Asia Fernández-Carvajal, Antonio Ferrer-Montiel
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-10-01 |
Deskripsi
A mouse model of chronic migraine reveals that males recover normal sensitivity before than females. This antinociception requires TRPM8 expression and presence of testosterone, which elicits currents and calcium transients via human and murine TRPM8.