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Lack of Efficacy of Albendazole against <i>Dicrocoelium dendriticum</i> Infection in a Sheep Farm in France
oleh: Julie Petermann, Christelle Grisez, Sophie Lavigne, Philippe Jacquiet
Format: | Article |
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Diterbitkan: | MDPI AG 2024-07-01 |
Deskripsi
Dicrocoeliosis is a common parasitic disease in European sheep farming. The prevalence of infection by this parasite can reach almost 70% in areas where the environment is favorable to intermediate hosts. In France, only one drug is currently available for the treatment of dicrocoeliosis: albendazole at a dose of 15 mg/kg in a single administration. However, a control coproscopy following a routine treatment led us to suspect that the efficacy of albendazole against <i>Dicrocoelium dendriticum</i> had diminished. Therefore, we carried out an efficacy test on 15 animals by treating them with albendazole at a dose of 15 mg/kg and performing a coproscopy on D0 and a control coproscopy 14 days later. We obtained a 39% reduction in the excretion of <i>D. dendriticum</i> eggs. This shows a reduction in the expected efficacy of albendazole, which is normally more than 90% in other studies involving this molecule at a dosage of 15 mg/kg. These results are of major concern as albendazole is currently the only drug available in France to treat dicrocoeliosis.