Determinants of RPA megafoci localization to the nuclear periphery in response to replication stress
oleh: Seong Min Kim, Susan L Forsburg
| Format: | Article |
|---|---|
| Diterbitkan: | Oxford University Press 2022-05-01 |
Deskripsi
AbstractUpon replication stress, ssDNA, coated by the ssDNA-binding protein RPA, accumulates and generates a signal to activate the replication stress response. Severe replication stress induced by the loss of minichromosome maintenance helicase subunit Mcm4 in the temperature-sensitive Schizosaccharomyces pombemcm4-dg