Actin nucleation at the centrosome controls lymphocyte polarity
Autor: Dorian Obino, Francesca Farina, Odile Malbec, Pablo J. Sáez, Mathieu Maurin, Jérémie Gaillard, Florent Dingli, Damarys Loew, Alexis Gautreau, Maria-Isabel Yuseff, Laurent Blanchoin, Manuel Théry, Ana-Maria Lennon-Duménil
| Médium: | Article |
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| Vydáno: | Nature Portfolio 2016-03-01 |
Popis
Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al. show that in lymphocytes centrosome-associated Arp2/3 nucleates actin that tethers the centrosome to the nucleus; activation depletes Arp2/3 from the centrosome and frees it from the nucleus.