Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>
oleh: Yanjun Sun, Haojie Chen, Junmin Wang, Meiling Gao, Chen Zhao, Ruijie Han, Hui Chen, Meng Li, Guimin Xue, Weisheng Feng
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-09-01 |
Deskripsi
Sixteen new prenylated flavonoids, sinoflavonoids P−Z (<b>1</b>−<b>11</b>) and sinoflavonoids NA−NE (<b>12</b>−<b>16</b>), were isolated from the fruit of <i>Sinopodophyllum hexandrum</i>, along with eight known analogues (<b>17</b>−<b>24</b>). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, HSQC, HMBC). The cytotoxic activities of compounds <b>1</b>−<b>18</b>, <b>20</b>, and <b>22</b> were evaluated by MTT assay. Compound <b>6</b> showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC<sub>50</sub> values of 6.25 and 3.83 μM, respectively.