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Aim: This study was done with an aim to evaluate the effect of 0.10% sodium hypochlorite in chronic periodontitis patients. Materials and Method: The study included 30 patients diagnosed with chronic generalized periodontitis who reported to the Department of Periodontology at Karnavati School of Dentistry. The duration of the study was 3 months with 30 patients are randomly divided into 2 groups. The test group consisted of 15 patients who were advised to rinse with 15 mL of a fresh solution of 0.10% sodium hypochlorite (test) for 30 seconds whereas the control group patients were advised to rinse with 15 mL of water (control) twice weekly. The test group patients received professional subgingival irrigation for 5 minutes with 0.10% sodium hypochlorite at baseline, 1st month, 2nd month and 3rd month and the control group patients received professional subgingival irrigation for 5 minutes with water, but no subgingival or supragingival scaling was undertaken. The cl inical parameters recorded were: Turesky et al modification of Quigley hein index (1970), Gingival index (1963) and Papillary Marginal Attachment index by Schour and Massler (1947). All the parameters were recorded at the baseline, 1 st month, 2nd month and 3rd month. Adverse events were evaluated by questionnaire and visual examination. Result: All 30 patients in the study completed the 3-month study. The differences in clinical parameters between the sodium hypochlorite rinse group and the water rinse group were statistically significant. No adverse events were reported by any of the study patients. Conclusion: The results from the study showed that rinsing with 0.10% sodium hypochlorite led to decrease in dental plaque level and bleeding on probing and may prove to be a promising new approach for the management of periodontal disease.