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Adenosquamous carcinoma (ASC) is an uncommon tumor of the head and neck and is histologically characterized by the presence of both glandular and squamous components. In this article, we describe a 42-year-old male patient who presented with a left neck mass for about 2 months. Direct microlaryngoscopy with biopsy demonstrated adenosquamous carcinoma. We also discuss the results of a brief review of the literature for the clinical features, histopathological characteristics, and treatment strategies for ASC. Keywords: Adenosquamous carcinoma, Head and neck, Hypopharynx, Mucicarmine stain, CK5/6, Therapy