Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
oleh: Gabriel Amitai, Alexander Plotnikov, Shira Chapman, Shlomi Lazar, Rellie Gez, Dan Loewenthal, Khriesto A. Shurrush, Galit Cohen, Leonardo J. Solmesky, Haim Barr, Alan J. Russell
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-05-01 |
Deskripsi
Amitai et al. identified 4 potential small molecule antidotes toward nerve agents poisoning by high-throughput-screening of over 150,000 compounds. Unique non-quaternary oximes represent new potential antidotes for future development as they detoxified nerve agents and also reactivated nerve agent-inhibited butyrylcholinesterase.