Elucidating the role of metal ions in carbonic anhydrase catalysis
oleh: Jin Kyun Kim, Cheol Lee, Seon Woo Lim, Aniruddha Adhikari, Jacob T. Andring, Robert McKenna, Cheol-Min Ghim, Chae Un Kim
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-09-01 |
Deskripsi
Metalloenzymes often show different catalytic activities in the presence of non-native metal ions. Here, the authors report structures of carbonic anhydrase bound to zinc and several other metal ions and demonstrate that metal ion coordination geometries directly impact catalytic activity of the enzyme.