Synthesis of a novel analogue of DPP-4 inhibitor Alogliptin: Introduction of a spirocyclic moiety on the piperidine ring
oleh: Arumugam Kodimuthali, Padala Lakshmi Prasunamba, Manojit Pal
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2010-07-01 |
Deskripsi
We report the synthesis of a novel analogue of Alogliptin via condensation of two key intermediates one of which is an aminopiperidine derivative bearing a spirocyclic ring on the piperidine moiety. Preparation of the aminopiperidine intermediate was carried out by constructing the cyclopropyl ring prior to assembling the piperidine ring.