Innate Immune Evasion of Alphaherpesvirus Tegument Proteins
oleh: Linjiang Yang, Linjiang Yang, Linjiang Yang, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Renyong Jia, Renyong Jia, Renyong Jia, Mafeng Liu, Mafeng Liu, Mafeng Liu, Dekang Zhu, Dekang Zhu, Dekang Zhu, Shun Chen, Shun Chen, Shun Chen, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Juan Huang, Juan Huang, Juan Huang, Yin Wang, Yin Wang, Yin Wang, Zhiwen Xu, Zhiwen Xu, Zhiwen Xu, Zhengli Chen, Zhengli Chen, Zhengli Chen, Ling Zhu, Ling Zhu, Ling Zhu, Qihui Luo, Qihui Luo, Qihui Luo, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Bin Tian, Bin Tian, Leichang Pan, Leichang Pan, Mujeeb Ur Rehman, Mujeeb Ur Rehman, Xiaoyue Chen, Xiaoyue Chen, Xiaoyue Chen
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2019-09-01 |
Deskripsi
Alphaherpesviruses are a large family of highly successful human and animal DNA viruses that can establish lifelong latent infection in neurons. All alphaherpesviruses have a protein-rich layer called the tegument that, connects the DNA-containing capsid to the envelope. Tegument proteins have a variety of functions, playing roles in viral entry, secondary envelopment, viral capsid nuclear transportation during infection, and immune evasion. Recently, many studies have made substantial breakthroughs in characterizing the innate immune evasion of tegument proteins. A wide range of antiviral tegument protein factors that control incoming infectious pathogens are induced by the type I interferon (IFN) signaling pathway and other innate immune responses. In this review, we discuss the immune evasion of tegument proteins with a focus on herpes simplex virus type I.