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Zoonoses are a significant public health concern and cause considerable socioeconomic problems globally. The emergence of severe acute respiratory syndrome (SARS), highly pathogenic avian influenza (HPAI), and Ebola virus disease (EVD) has had a significant effect on the national economy and public health in China, and other countries. This review analyzed zoonotic disease issues faced by China, and the main factors contributing to the risk of zoonotic disease. The Chinese government has devised new strategies and has taken measures to deal with the challenges of these diseases, and the prevention and control of zoonoses at their source. A strategy that is suited to China's national conditions, is proposed.