Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice
oleh: Yoshito Yamada, Tuan Thanh Nguyen, Daniela Impellizzieri, Katsutaka Mineura, Rintaro Shibuya, Alvaro Gomariz, Martina Haberecker, Jakob Nilsson, César Nombela-Arrieta, Wolfgang Jungraithmayr, Onur Boyman
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-03-01 |
Deskripsi
IL-2/anti-IL-2 antibody complexes have been shown to facilitate the process of graft acceptance in transplantation. Here the authors use a mouse allograft model to show that IL-2 complexes promote graft acceptance and formation of inducible lymphoid structures containing Treg cells in transplanted lungs.