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A 4-year-old girl diagnosed with stage III hepatoblastoma presented for tumor resection. She had received four neoadjuvant cycles of cisplatin, 5-fluorouracil, and doxorubicin with good response. On perioperative imaging, several ring-enhancing lesions were noted in the liver concerning for satellite lesions vs. infectious etiology. A biopsy revealed abscess due to Escherichia coli, so the patient was admitted to receive intravenous antibiotics. Ten days after admission, the liver lesions had decreased in size and a right hemihepatectomy was performed to resect the primary tumor. The patient recovered uneventfully on 7 additional days of antibiotics, with resolution of liver abscess on repeat imaging.