Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2
oleh: Maria Jussila, Curtis W. Boswell, Nigel W. Griffiths, Patrick G. Pumputis, Brian Ciruna
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
Planar cell polarity (PCP) is critical for tissue-wide coordination and successful development. Here Jussila et al. generate a GFP-Vangl2 fusion for live imaging and discover a surprising directionality to the intercellular propagation of cell polarity, and ultimately link PCP defects with idiopathic scoliosis.