Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
oleh: Anren Song, Yujin Zhang, Leng Han, Gennady G. Yegutkin, Hong Liu, Kaiqi Sun, Angelo D’Alessandro, Jessica Li, Harry Karmouty-Quintana, Takayuki Iriyama, Tingting Weng, Shushan Zhao, Wei Wang, Hongyu Wu, Travis Nemkov, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Kirk C. Hansen, Hong Zhang, Mikhail Bogdanov, William Dowhan, Jianping Jin, Rodney E. Kellems, Holger K. Eltzschig, Michael Blackburn, Robert C. Roach, Yang Xia
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2017-02-01 |
Deskripsi
Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Songet al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter ENT1 resulting from coordinated adenosine generation by ectonucleotidase CD73 and activation of A2B receptors.