Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine <i>N</i>-Oxides with Anti-Influenza A Virus Activity
oleh: Claudio Zippilli, Lorenzo Botta, Bruno Mattia Bizzarri, Lucia Nencioni, Marta De Angelis, Virginia Protto, Gianluca Giorgi, Maria Camilla Baratto, Rebecca Pogni, Raffaele Saladino
| Format: | Article |
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| Diterbitkan: | MDPI AG 2021-01-01 |
Deskripsi
Belladine <i>N</i>-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine <i>N</i>-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle.