Cross-reactive microbial peptides can modulate HIV-specific CD8+ T cell responses.
oleh: Christopher W Pohlmeyer, Sarah B Laskey, Sarah E Beck, Daniel C Xu, Adam A Capoferri, Caroline C Garliss, Megan E May, Alison Livingston, Walt Lichmira, Richard D Moore, M Sue Leffell, Nicholas J Butler, Jennifer E Thorne, John A Flynn, Robert F Siliciano, Joel N Blankson
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2018-01-01 |
Deskripsi
Heterologous immunity is an important aspect of the adaptive immune response. We hypothesized that this process could modulate the HIV-1-specific CD8+ T cell response, which has been shown to play an important role in HIV-1 immunity and control. We found that stimulation of peripheral blood mononuclear cells (PBMCs) from HIV-1-positive subjects with microbial peptides that were cross-reactive with immunodominant HIV-1 epitopes resulted in dramatic expansion of HIV-1-specific CD8+ T cells. Interestingly, the TCR repertoire of HIV-1-specific CD8+ T cells generated by ex vivo stimulation of PBMCs using HIV-1 peptide was different from that of cells stimulated with cross-reactive microbial peptides in some HIV-1-positive subjects. Despite these differences, CD8+ T cells stimulated with either HIV-1 or cross-reactive peptides effectively suppressed HIV-1 replication in autologous CD4+ T cells. These data suggest that exposure to cross-reactive microbial antigens can modulate HIV-1-specific immunity.