Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus
oleh: Ian A. Durie, Zahra R. Tehrani, Elif Karaaslan, Teresa E. Sorvillo, Jack McGuire, Joseph W. Golden, Stephen R. Welch, Markus H. Kainulainen, Jessica R. Harmon, Jarrod J. Mousa, David Gonzalez, Suzanne Enos, Iftihar Koksal, Gurdal Yilmaz, Hanife Nur Karakoc, Sanaz Hamidi, Cansu Albay, Jessica R. Spengler, Christina F. Spiropoulou, Aura R. Garrison, Mohammad M. Sajadi, Éric Bergeron, Scott D. Pegan
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
There are currently no approved treatments for Crimean-Congo Hemorrhagic Fever Virus (CCHFV) infection. In this study, the authors structurally characterize the epitope targeted by protective non-neutralizing mouse and human antibodies and provide insights into their broad range potential against various CCHFV strains.