Four New Antibacterial Xanthones from the Marine-Derived Actinomycetes Streptomyces caelestis
oleh: Pei-Yuan Qian, Xi-Xiang Zhang, Xian-Rong Guo, Jia-Liang Zhong, Pok-Yui Lai, Yong-Xin Li, Liang Lu, Zhuang Han, Ying Xu, Ling-Li Liu
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2012-11-01 |
Deskripsi
Four new polycyclic antibiotics, citreamicin θ A (1), citreamicin θ B (2), citreaglycon A (3), and dehydrocitreaglycon A (4), were isolated from marine-derived Streptomyces caelestis. The structures of these compounds were elucidated by 1D and 2D NMR spectra. All four compounds displayed antibacterial activity against Staphylococcus haemolyticus, Staphylococcus aureus, and Bacillus subtillis. Citreamicin θ A (1), citreamicin θ B (2) and citreaglycon A (3) also exhibited low MIC values of 0.25, 0.25, and 8.0 μg/mL, respectively, against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300.