Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage
oleh: Jasper Panten, Stefania Del Prete, James P. Cleland, Lauren M. Saunders, Job van Riet, Anja Schneider, Paul Ginno, Nina Schneider, Marie-Luise Koch, Xuqi Chen, Moritz Gerstung, Oliver Stegle, Arthur P. Arnold, James M. A. Turner, Edith Heard, Duncan T. Odom
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2024-10-01 |
Deskripsi
Abstract The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y Sry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.