Generation of iPSC lines from a Nijmegen Breakage Syndrome patient
oleh: Barbara Mlody, James Adjaye
| Format: | Article |
|---|---|
| Diterbitkan: | Elsevier 2015-11-01 |
Deskripsi
Human dermal fibroblasts from a Nijmegen Breakage Syndrome (NBS) patient bearing the 657del5 mutation within the DNA repair gene NIBRIN were used to generate two iPSC-lines (vNBS8-iPS-c1, vNBS8-iPS-c2) by retroviral transduction of OCT4, SOX2, c-MYC and KLF4. Pluripotency was confirmed both in vivo and in vitro.