Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform
oleh: William Whyte, Debkalpa Goswami, Sophie X. Wang, Yiling Fan, Niamh A. Ward, Ruth E. Levey, Rachel Beatty, Scott T. Robinson, Declan Sheppard, Raymond O’Connor, David S. Monahan, Lesley Trask, Keegan L. Mendez, Claudia E. Varela, Markus A. Horvath, Robert Wylie, Joanne O’Dwyer, Daniel A. Domingo-Lopez, Arielle S. Rothman, Garry P. Duffy, Eimear B. Dolan, Ellen T. Roche
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Drug delivery implants suffer from diminished release profiles due to fibrous capsule formation over time. Here, the authors use soft robotic actuation to modulate the immune response of the host to maintain drug delivery over the longer-term and to perform controlled release in vivo.