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Objective: To determine the efficacy of 2% Lidocaine instillation for endotracheal tube cuff inflation versus air on postextubation cough. Study Design: Quasi-experimental study. Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, from May to Nov 2018. Methodology: The study was carried out on 64 patients undergoing surgery under general anaesthesia of a duration greater than one hour. Patients with respiratory pathology, risk of aspiration, difficult airway, and who need postop ventilator support were excluded. Patients were divided into Group-A (inflated with air) and Group-L (inflated with 2% Lidocaine) by sealed opaque envelop method. Post-extubation cough and one hour later was recorded. Results: The mean age of Group-A and Group-L was 30.06±4.36 years and 29.66±4.45 years, respectively. 43(67.19%) participants were males, whereas 21(32.81%) were females. The efficacy of 2% Lignocaine versus air in endotracheal cuff on post-extubation cough and one hour following extubation in Group-A was 19(59.38%) and 11(34.38%), respectively. This was reduced to 06(18.75%) and 1(3.13%) in Group-L, respectively (p<0.05). Conclusion: This study concluded that using 2% Lidocaine for inflation of the endotracheal tube cuff decreases the cough frequency after extubation compared to air.