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Four new dimeric sorbicillinoids (<b>1</b>–<b>3</b> and <b>5</b>) and a new monomeric sorbicillinoid (<b>4</b>) as well as six known analogs (<b>6</b>–<b>11</b>) were purified from the fungal strain <i>Hypocrea jecorina</i> H8, which was obtained from mangrove sediment, and showed potent inhibitory activity against the tea pathogenic fungus <i>Pestalotiopsis theae</i> (<i>P. theae</i>). The planar structures of <b>1</b>–<b>5</b> were assigned by analyses of their UV, IR, HR-ESI-MS, and NMR spectroscopic data. All the compounds were evaluated for growth inhibition of tea pathogenic fungus <i>P. theae</i>. Compounds <b>5</b>, <b>6</b>, <b>8</b>, <b>9</b>, and <b>10</b> exhibited more potent inhibitory activities compared with the positive control hexaconazole with an ED₅₀ of 24.25 ± 1.57 µg/mL. The ED₅₀ values of compounds <b>5</b>, <b>6</b>, <b>8</b>, <b>9</b>, and <b>10</b> were 9.13 ± 1.25, 2.04 ± 1.24, 18.22 ± 1.29, 1.83 ± 1.37, and 4.68 ± 1.44 µg/mL, respectively. Additionally, the effects of these compounds on zebrafish embryo development were also evaluated. Except for compounds <b>5</b> and <b>8</b>, which imparted toxic effects on zebrafish even at 0.625 μM, the other isolated compounds did not exhibit significant toxicity to zebrafish eggs, embryos, or larvae. Taken together, sorbicillinoid derivatives (<b>6</b>, <b>9</b>, and <b>10</b>) from <i>H. jecorina</i> H8 displayed low toxicity and high anti-tea pathogenic fungus potential.