Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
oleh: David Osuna de la Peña, Sara Maria David Trabulo, Estelle Collin, Ying Liu, Shreya Sharma, Marianthi Tatari, Diana Behrens, Mert Erkan, Rita T. Lawlor, Aldo Scarpa, Christopher Heeschen, Alvaro Mata, Daniela Loessner
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-09-01 |
Deskripsi
Personalized cancer medicine currently lacks custom platforms that mimic the microenvironment of human tissues. Here, the authors show how self-assembled patient-derived models of pancreatic cancer recapitulate key biological features of the original tumours such as matrix composition and stemness.