A mitochondrial response to oxidative stress mediated by unscheduled RNA-DNA hybrids (R-loops)
oleh: Xavier Renaudin, Ashok R. Venkitaraman
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2021-11-01 |
Deskripsi
How oxidative stress promotes aging-related human diseases like cancer and neurodegeneration remains unclear. Here, we discuss the origins and implications of an oxidative-stress response recently reported to destabilize the mitochondrial (mt) genome via unscheduled RNA/DNA hybrid (R-loop) accumulation, by impairing the recruitment of RNAseH1 to the regulatory regions of mtDNA.