Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics
oleh: Wan-Hong Wen, Yue Zhang, Ying-Ying Zhang, Qian Yu, Chu-Chu Jiang, Man-Cheng Tang, Jin-Yue Pu, Lian Wu, Yi-Lei Zhao, Ting Shi, Jiahai Zhou, Gong-Li Tang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-12-01 |
Deskripsi
Antibiotic-producing organisms need to co-evolve self-protection mechanisms to avoid any damage to themselves caused by the antibiotic pharmacophore (the reactive part of the compound). In this study, the authors report a self-defense strategy in naphthyridinomycin (NDM)-producing Streptomyces lusitanus, that comprises reductive inactivation of the hemiaminal pharmacophore by short-chain dehydrogenases/reductases (SDRs) NapW and HomW.