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Blood donors, as the core of blood collection and supply system, can greatly ensure blood safety and meet clinical demands with effective management. Good donor practice (GDP) is based on the cooperation of multiple departments by multiple methods. In accordance with the principles of science and ethnic, according to the number and frequency of blood donation and blood donation behavior, GDP classified blood donors accurately, and built up a procedure including potential blood donor identification, selection, recruitment, retention and caring to maintain an accurate management system for keeping regular blood donors. The evaluation indicators for the operation of GDP system were set to conduct real-time monitoring and evaluation, so as to achieve efficient and accurate management and ensure the long-term and stable supply of blood resources.