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<i>Narcissus</i> L. is a renowned plant genus with a notable center of diversity and is primarily located in the Mediterranean region. These plants are widely recognized for their ornamental value, owing to the beauty of their flowers; nonetheless, they also hold pharmacological importance. In Europe, pharmaceutical companies usually use the bulbs of <i>Narcissus pseudonarcissus</i> cv. Carlton to extract galanthamine, which is one of the few medications approved by the FDA for the palliative treatment of mild-to-moderate symptoms of Alzheimer’s disease. The purpose of this study was to evaluate the potential of these plants in Alzheimer’s disease. The alkaloid extract from the leaves of different species of <i>Narcissus</i> was obtained by an acid-base extraction work-up -procedure. The biological potential of the samples was carried out by evaluating their ability to inhibit the enzymes acetyl- and butyrylcholinesterase (AChE and BuChE, respectively). The species <i>N. jacetanus</i> exhibited the best inhibition values against AChE, with IC₅₀ values of 0.75 ± 0.03 µg·mL⁻¹, while <i>N. jonquilla</i> was the most active against BuChE, with IC₅₀ values of 11.72 ± 1.15 µg·mL⁻¹.