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Objective To study both non-invasive continuous cardiac index (CCI) and risk factors of coronary heart disease related with left ventricular ejection fraction (LVEF). Methods Retrospective study was done at VIP Health Center with 90 patients with preanesthesia assessment for gastrointestinal endoscopy under intravenous anesthesia between January and March 2022 in our hospital. CCI was measured using non-invasive real-time arterial blood pressure and hemodynamic monitoring system. Risk factors of coronary heart disease were collected. There were three groups of patients according to the results of LVEF gotten from echocardiography examination including group of LVEF 40%-49% (n=15), group of LVEF 50%-59% (n=38) and group of LVEF >60% (n=37). Results The group of LVEF 40%-49% had the highest rate of smoking (60.0%), hypertension (80.0%), diabetes (73.3%), hyperlipidemia (86.6%), obesity (53.3%), family history of early onest cardiovascular disease (33.3%) and the highest rate of ≥3 risk factors of coronary heart disease (80.0%)(P<0.05). The CCI in the group of LVEF 40%-49% was the lowest among three groups (P<0.05). There was a significant positive correlation between CCI and LVEF (r>0.95, P<0.05). Conclusions It was suggested that non-invasive real-time arterial blood pressure and hemodynamic monitoring system could be used for preanesthesia assessment, and CCI related to LVEF, which improves the safety of anesthesia for patients.