MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner
oleh: Inés Paniagua, Zainab Tayeh, Mattia Falcone, Santiago Hernández Pérez, Aurora Cerutti, Jacqueline J. L. Jacobs
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
MAD2L2 – as a member of the shieldin complex - counteracts resection during DNA repair. Here the authors demonstrate that MAD2L2 protects stalled replication forks from excessive resection, in a shieldin-independent and REV3L-dependent manner.