Opportunities and challenges of hepatocellular carcinoma organoids for targeted drugs sensitivity screening
oleh: Cuiying Xie, Cuiying Xie, Ancheng Gu, Ancheng Gu, Muhammad Khan, Xiangcao Yao, Xiangcao Yao, Leping Chen, Leping Chen, Jiali He, Jiali He, Fumiao Yuan, Fumiao Yuan, Ping Wang, Ping Wang, Yufan Yang, Yufan Yang, Yerong Wei, Yerong Wei, Fang Tang, Fang Tang, Hualong Su, Hualong Su, Jiamin Chen, Jiamin Chen, Jinxia Li, Jinxia Li, Bohong Cen, Bohong Cen, Bohong Cen, Zhongyuan Xu, Zhongyuan Xu
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2023-01-01 |
Deskripsi
Hepatocellular carcinoma is one of the malignancies worldwide with a high mortality rate and an increasing incidence. Molecular Targeted agents are its common first-line treatment. Organoid technology, as a cutting-edge technology, is gradually being applied in the development of therapeutic oncology. Organoid models can be used to perform sensitivity screening of targeted drugs to facilitate the development of innovative therapeutic agents for the treatment of hepatocellular carcinoma. The purpose of this review is to provide an overview of the opportunities and challenges of hepatocellular carcinoma organoids in targeted drug sensitivity testing as well as a future outlook.