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Boce Liu,1 Wenjing Wang,1 Jianhai Bi,2,* Ran Huo1,2,* 1Department of Plastic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China; 2Department of Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianhai Bi, Department of Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China, Tel +86-15110080702, Fax +86 531-68778160, Email bijianhai@126.com Ran Huo, Department of Plastic Surgery, Shandong Provincial Hospital of Shandong University, Jinan, Shandong, People’s Republic of China, Tel +86-15168889001, Fax +86 531-68778153, Email huoran@medmail.com.cnAbstract: Follicular occlusion tetrad (FOT) is a chronic inflammatory skin disease that seriously affects patients’ quality of life. At present, there is no standard treatment plan for FOT. We report the case of a 50-year-old male patient diagnosed as having FOT with Fordyce granules and type 2 diabetes mellitus. During hospitalization, the patient received comprehensive and systematic treatment. The patient healed well after surgery and the 10-month follow-up revealed no recurrence. We found eight gene mutations by whole-exome sequencing (WES) of the patient’s peripheral blood.Keywords: follicular occlusion tetrad, Fordyce granules, gene analysis, comprehensive treatment