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Asphaltene deposition not only damages reservoir physical properties, but also affects fluid saturation distribution and seepage characteristics.The oil-water, oil-gas and three-phase relative permeability curves with or without asphaltene deposition were measured by long core displacement experiments under different development modes, and the effects of asphaltene deposition on oil relative permeability and rock wettability were studied.The results show that the asphaltene deposition reduces the oil recovery by 12.2%, 5.9% and 15.3% for water flooding, CO2 immiscible flooding and water-altemating-gas WAG flooding, respectively.And it will cause the displacement pressure difference to rise, the wettability of rock to change to lipophilic, and accelerate the breakthrough time of water/gas.Asphaltene precipitation in water flooding will make the oil-water two-phase co permeability zone move to the left, and the influence of water saturation on oil phase relative permeability increases.In CO2 immiscible flooding, asphaltene precipitation has little effect on gas permeability, while oil permeability is more easily affected by the change of gas saturation.In three-phase flow, asphaltene precipitation can reduce oil permeability, accelerate the decline of oil relative permeability, increase residual oil saturation and weaken WAG flooding effect.After adding JCF-1 nonionic surfactant into the injected water, the displacement pressure difference can be reduced, the breakthrough time of water/gas can be delayed, the relative permeability of oil phase can be increased, the residual oil saturation can be reduced, and the damage caused by asphaltene deposition can be made up.The research results provide a basis for efficient development of asphaltene rich reservoirs.