Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
oleh: Kelvin Chan, Jacquelyn Nestor, Tomás S. Huerta, Noele Certain, Gabrielle Moody, Czeslawa Kowal, Patricio T. Huerta, Bruce T. Volpe, Betty Diamond, Lonnie P. Wollmuth
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2020-03-01 |
Deskripsi
Systemic lupus erythematosus (SLE) is an autoimmune disorder which can have neurological manifestations, including autoantibody targeting of the NMDA receptor. In this study, the authors GluN2A subunit is a target of SLE autoantibodies, using sample derived from patient.