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Abstract Isospin symmetry is the most precise flavor symmetry. The effective Hamiltonian of charm quark weak decay is zero under the isospin lowering operators $$I_-^n$$ I - n , which permits us to generate isospin sum rules through several master formulas. In this work, we derive the master formulas of isospin sum rules for the two- and three-body non-leptonic decays of singly and doubly charmed baryons. Hundreds of isospin sum rules are derived to test of isospin symmetry and provide hints for the new decay modes. The isospin sum rules for multi-body decays are not broken by the intermediate resonances and hence can be used to study the isospin partners of exotic hadrons.