Engineering rules that minimize germline silencing of transgenes in simple extrachromosomal arrays in C. elegans

oleh: Mohammed D. Aljohani, Sonia El Mouridi, Monika Priyadarshini, Amhed M. Vargas-Velazquez, Christian Frøkjær-Jensen

Format: Article
Diterbitkan: Nature Portfolio 2020-12-01

Deskripsi

C. elegans has strong repressive mechanisms that silence transgenes in the germline. Here the authors elucidate the design rules for efficient germline expression.