Sustained suppression of enterohepatic circulation of mycophenolic acid by antimicrobial‐associated diarrhea in a kidney transplant recipient with Crohn's disease: A case report
oleh: Ryota Tanaka, Asami Matsumoto, Ryosuke Tatsuta, Tadasuke Ando, Toshitaka Shin, Hiromitsu Mimata, Hiroki Itoh
| Format: | Article |
|---|---|
| Diterbitkan: | Wiley 2022-06-01 |
Deskripsi
Abstract Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial‐associated diarrhea. Consequently, the MPA trough level decreased by approximately 90%. Furthermore, it took approximately a month for the MPA level to normalize even after diarrhea had resolved.