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Infective endocarditis is often caused by bacterial pathogens and can affect native and prosthetic tissue. Common pathogens in pediatric patients include Staphylococcus aureus, viridans group streptococci, enterococcal species and coagulase-negative staphylococci, though culture-negative cases are not uncommon. Coagulase-negative staphylococci present a conundrum to clinicians due to the potential of culture contamination. While Staphylococcus lugdunensis is a coagulase-negative staphylococcus, it is an emerging cardiotropic pathogen that presents similarly to Staphylococcus aureus. Here we report a case of a child with repaired tetralogy of Fallot found to have right-sided infective endocarditis caused by Staphylococcus lugdunensis.