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Calciphylaxis is a rare, life-threatening syndrome of vascular calcification, and the pathogenesis of the disease is not well demonstrated. Here, we presented a 33-year-old Chinese male, treated with continuous ambulatory peritoneal dialysis (CAPD) for 5 years with recent onset of calciphylaxis was described. The initial laboratorial workup showed severely elevated intact parathyroid, procalcitonin and serum phosphorus. The main signs were massive pumps in his shoulder and sternum, and necrotic ulcer covered with a black eschar on the right middle finger. The main incentive of calciphylaxis might be the misuse of vitamin-D receptor analogs.