Find in Library

<p><b>Purpose:</b> Antimicrobial resistance among microorganisms is a global concern. In 2003, a nationwide antibiotic restriction program (NARP) was released in Turkey. In this study we evaluated the effect of NARP on antibiotic consumption, antimicrobial resistance, and cost.</p><p><b>Materials and Methods:</b> The data obtained from all of the four university hospitals, and one referral tertiary-care educational state hospital in Ankara. Antimicrobial resistance profiles of 14,233 selected microorganisms all grown in blood cultures and antibiotic consumption from 2001 to 2005 were analyzed retrospectively.</p><p><b>Results</b>: A negative correlation was observed between the ceftriaxone consumption and the prevalence of ceftriaxone resistant <i>E.coli </i>and <i>Klebsiella </i>spp<i>.</i> (rho:-0.395, <i>p</i>:0.332 and rho:-0.627,<i> p</i>:0.037, respectively). The decreased usage of carbapenems was correlated with decreased carbapenems-resistant <i>Pseudomonas</i> spp<i>.</i> and <i>Acinetobacter </i>spp (rho:0.155,<i> p</i>:0.712 and rho:0.180, <i>p</i>:0.668, respectively for imipenem). Methicillin resistance rates of <i>S.aureus</i> were decreased from 44% to 41%. After two years of NARP 5,389,155.82 USD saving occurred.</p><p><b>Conclusion:</b> NARP is effective in lowering the costs and antibiotic resistance.</p>