Regulation of miR-181a expression in T cell aging
oleh: Zhongde Ye, Guangjin Li, Chulwoo Kim, Bin Hu, Rohit R. Jadhav, Cornelia M. Weyand, Jörg J. Goronzy
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
MicroRNA miR-181a has been implicated in the regulation of T cell activation and development. Here the authors show that miR-181a is regulated by a transcription factor, YY1, with reduced YY1 expression linked to reduced miR-181a in old individuals, while silencing YY1 impairs T cell functions largely through influencing the expression of miR-181a targets.