Aristolactam-Type Alkaloids from Orophea enterocarpa and Their Cytotoxicities
oleh: Narong Nuntasaen, Wilart Pompimon, Wirote Tuntiwechapikul, Puttinan Meepowpan, Pak Thaichana, Mongkol Buayairaksa, Sanchai Nayyatip
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2012-04-01 |
Deskripsi
A new aristolactam, named enterocarpam-III (10-amino-2,3,4,6-tetramethoxy phenanthrene-1-carboxylic acid lactam, 1) together with the known alkaloid stigmalactam (2), were isolated from Orophea enterocarpa. Their structures were elucidated on the basis of interpretation of their spectroscopic data. Compounds 1 and 2 exhibited significant cytotoxicities against human colon adenocarcinoma (HCT15) cell line with IC50 values of 1.68 and 1.32 μM, respectively.