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The issue of intrinsic microstructural and mechanical instability of Zn-based metals limits their expansion in potential applications of bioresorbable stents and orthopedic fixators. A new concept of stabilization of Zn microstructure by a small fraction of nontoxic nanometric ZnO dispersoids is proposed for the first time and demonstrated on the particular bioabsorbable model material. The effect of the ZnO dispersoids on post-processing microstructural stability, deformation and strengthening mechanisms, corrosion, and in-vitro biological behavior are pursued. The ZnO dispersoids arise in situ within deformed Zn structure during the consolidation of fine atomized Zn 99.99wt.% powder by hydro-extrusion. ZnO nanodispersoids (4.75 vol.%; ∼136 nm) form from passivating films present on Zn. They allow formation of ultrafine-grained Zn structure with an average grain size of ∼750 nm and its retention by Zener pinning action during annealing held at 100 °C. The model Zn + ZnO composite shows the superior mechanical properties than those reported for pure Zn materials. The utilized stabilization concept doesn't compromise corrosion and biological responses. Immersion of the Zn + ZnO in DMEM results in a corrosion rate, which complies with the desirable standard rate for biodegradable materials. Electrochemical tests suggest that the Zn + ZnO reaches a similar degradation rate after the first week of immersion and a more uniform corrosion behavior compared to the cast Zn reference. In-vitro cyto/genotoxicity assays performed using DMEM diluted extracts of the Zn + ZnO and cast Zn incubated with L929 cells yield in comparable and non-toxic responses. The presence of ZnO dispersoids induces a small but still significant bacteriostatic activity.